Family history of autoimmune thyroid disease and childhood acute leukemia.

Short Communication Family History of Autoimmune Thyroid Disease and Childhood Acute Leukemia

The association between a familial history of autoimmune disease and childhood acute leukemia was investigated in a French case-control study that, overall, was designed to assess the role of perinatal, infectious, environmental, and genetic factors in the etiology of childhood acute leukemia. Familial histories of autoimmune disease in firstand second-degree relatives were compared in 279 inci...

Evaluation of Relationship between Minimal Residual Disease (MRD) and Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) Using Quantitative Fluorescent PCR

Central Hypothyroidism: A Rare Complication in a Child Undergoing Chemotherapy for Acute Lymphoblastic Leukemia

Abnormalities of the thyroid gland are among the most frequent endocrine complications observed in childhood cancer survivors. We report an 11 years old girl who developed central hypothyroidism and ACTH deficiency during the chemotherapy for CNS relapse of acute lymphoblastic leukemia before receiving radiotherapy. Keywords: Thyroid gland, hypothyroidism, chemotherapy, acute lymphoblastic leu...

Genome-wide Analysis of Long Non-coding Rna (lncrna) of Autoimmune Thyroid Diseases Using Bioinformatics Approaches

Objective: Long non-coding RNA’s (lncRNA’s) have a crucial role in cancer biology. In this study, the genome sequence analysis of lncRNA expression in autoimmune thyroid disease is done to identify novel targets for further study of the disease. Methods: All the data were collected from Disgenet and Ensemble genome browser. Gene ontology and network analysis were performed using the standard en...

Lineage Switch in Childhood Leukemia: A Case Report and Review of Literature

Acute leukemia which is the most common cancer in children is a heterogeneous group of clonal malignancies. The conversion of the leukemic cell lineage during the course of the disease or later is termed lineage switch. It has been rarely reported in the literature. In leukemia lineage switch, conversions from lymphoblastic leukemia to myeloid leukemia or vice versa are reported. Herein, we rep...